LymphedemaV1, Main, Exploration, bibRecord, 006052

Retrospective study of the surgical management and outcome of nonrhabdomyosarcoma soft tissue sarcomas of the groin and axilla in children

Identifieur interne : 006052 ( Main/Exploration ); précédent : 006051; suivant : 006053

Retrospective study of the surgical management and outcome of nonrhabdomyosarcoma soft tissue sarcomas of the groin and axilla in children

Auteurs : Gideon Karplus [États-Unis] ; Matthew J. Krasin [États-Unis] ; Carlos Rodriguez-Galindo [États-Unis] ; Beth Mccarville [États-Unis] ; Jesse Jenkins [États-Unis] ; Bhaskar Rao [États-Unis] ; George Spyridis [États-Unis] ; Sheri L. Spunt [États-Unis]

Source :

Journal of pediatric surgery [ 0022-3468 ] ; 2009.

RBID : PMC:3748624

Abstract

Background/Purpose

The incidence of pediatric NRSTSs of the groin and axilla is unknown, and the optimal surgical approach to these patients is unclear.

Methods

We conducted a retrospective study of patients treated at St. Jude Children's Research Hospital from January 1962 to March 2007 for NRSTSs of the groin and axilla. Demographic variables, tumor pathology, clinical management, and outcome were reviewed.

Results

Of the 300 patients treated for NRSTSs, only 10 had tumors of the axilla or groin (6 of whom had synovial sarcoma). Surgical interventions included wide resection of the tumor (n=7), marginal resection (n=1), subtotal resection (n=1), and biopsy only (n=1). Six patients underwent lymph node sampling; all were negative for tumor. Short- and long-term surgical complications were rare. Four patients received adjuvant chemotherapy (n=3) and/or radiotherapy (n=2). At a median follow-up of 8.5 years, 7 of the 10 were surviving free of disease. Two of these patients died of tumor progression (1 with metastases at diagnosis and 1 with an unresectable tumor at diagnosis) and one patient who was free of NRSTS died of secondary breast carcinoma.

Conclusions

Pediatric NRSTSs of the axilla and groin are rare, but outcomes are similar to those of other patients with NRSTS. Wide local excision of the tumor with preservation of good limb function should be the surgical goal, and may be sufficient therapy in some cases.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748624

DOI: 10.1016/j.jpedsurg.2009.02.052
PubMed: 19853757
PubMed Central: 3748624

Affiliations:

États-Unis

Le document en format XML

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<affiliation wicri:level="1"><nlm:aff id="A4"> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA</nlm:aff>
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<author><name sortKey="Rao, Bhaskar" sort="Rao, Bhaskar" uniqKey="Rao B" first="Bhaskar" last="Rao">Bhaskar Rao</name>
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<wicri:regionArea> Department of International Outreach, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea>
<wicri:noRegion>TN 38105</wicri:noRegion>
</affiliation>
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<author><name sortKey="Spyridis, George" sort="Spyridis, George" uniqKey="Spyridis G" first="George" last="Spyridis">George Spyridis</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA</nlm:aff>
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<author><name sortKey="Spunt, Sheri L" sort="Spunt, Sheri L" uniqKey="Spunt S" first="Sheri L." last="Spunt">Sheri L. Spunt</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA and Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN 38105, USA</nlm:aff>
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<series><title level="j">Journal of pediatric surgery</title>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background/Purpose</title>
<p id="P1">The incidence of pediatric NRSTSs of the groin and axilla is unknown, and the optimal surgical approach to these patients is unclear.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We conducted a retrospective study of patients treated at St. Jude Children's Research Hospital from January 1962 to March 2007 for NRSTSs of the groin and axilla. Demographic variables, tumor pathology, clinical management, and outcome were reviewed.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Of the 300 patients treated for NRSTSs, only 10 had tumors of the axilla or groin (6 of whom had synovial sarcoma). Surgical interventions included wide resection of the tumor (<italic>n</italic>
=7), marginal resection (<italic>n</italic>
=1), subtotal resection (<italic>n</italic>
=1), and biopsy only (<italic>n</italic>
=1). Six patients underwent lymph node sampling; all were negative for tumor. Short- and long-term surgical complications were rare. Four patients received adjuvant chemotherapy (<italic>n</italic>
=3) and/or radiotherapy (<italic>n</italic>
=2). At a median follow-up of 8.5 years, 7 of the 10 were surviving free of disease. Two of these patients died of tumor progression (1 with metastases at diagnosis and 1 with an unresectable tumor at diagnosis) and one patient who was free of NRSTS died of secondary breast carcinoma.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Pediatric NRSTSs of the axilla and groin are rare, but outcomes are similar to those of other patients with NRSTS. Wide local excision of the tumor with preservation of good limb function should be the surgical goal, and may be sufficient therapy in some cases.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
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<tree><country name="États-Unis"><noRegion><name sortKey="Karplus, Gideon" sort="Karplus, Gideon" uniqKey="Karplus G" first="Gideon" last="Karplus">Gideon Karplus</name>
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<name sortKey="Jenkins, Jesse" sort="Jenkins, Jesse" uniqKey="Jenkins J" first="Jesse" last="Jenkins">Jesse Jenkins</name>
<name sortKey="Krasin, Matthew J" sort="Krasin, Matthew J" uniqKey="Krasin M" first="Matthew J." last="Krasin">Matthew J. Krasin</name>
<name sortKey="Mccarville, Beth" sort="Mccarville, Beth" uniqKey="Mccarville B" first="Beth" last="Mccarville">Beth Mccarville</name>
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<name sortKey="Spyridis, George" sort="Spyridis, George" uniqKey="Spyridis G" first="George" last="Spyridis">George Spyridis</name>
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Retrospective study of the surgical management and outcome of nonrhabdomyosarcoma soft tissue sarcomas of the groin and axilla in children

Retrospective study of the surgical management and outcome of nonrhabdomyosarcoma soft tissue sarcomas of the groin and axilla in children

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Abstract

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